The RL Premium is equipped with a Honda 3.5 liter six-cylinder engine that utilizes 24 valves. The VTEC engine is mated to a Honda 4-speed Transaxle. This configuration has proven to be a successful design for Acura.

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Standard equipment in the Q45 for 1999 and 2000 includes the 4.1 liter engine by Nissan, weighing in at 8 cylinders and thirty two valves. A 4-speed Automatic Transmission puts the power of the engine to the pavement. The has proven to be a popular configuration for the Q45.

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The Q45 Anniversary Edition is equipped with a Nissan 4.1 liter eight-cylinder engine that utilizes 32 valves. The engine is mated to a Jatco 4-speed Transmission. This configuration has proven to be a successful design for Infiniti.

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The restyled RX300 Base is equipped with a 3.0-liter six-cylinder engine that utilizes 24 valves. The engine is mated to a Toyota four-speed transaxle. This has resulted in an increase in horsepower and torque over the 1999 version.

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